A Counterintuitive Neutrophil-Mediated Pattern in COVID-19 Patients Revealed through Transcriptomics AnalysisArticle Published on 2022-12-302023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] asymptomatic patients COVID-19 epidemiology cytokine blunt gene signature machine learning natural language processing transcriptomics virus entry spike absence. [DOI] 10.3390/v15010104 PMC 바로가기
Multi-objective optimization identifies a specific and interpretable COVID-19 host response signatureArticle Published on 2022-12-212023-07-11 Journal: Cell Systems [Category] COVID19(2023년), [키워드] COVID-19 cross-reactivity epigenomics host response signature interpretability optimization plasmablasts robustness transcriptomics viral infection diagnosis. [DOI] 10.1016/j.cels.2022.11.008 PMC 바로가기
Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for Cryptococcus neoformans invasion into the brain원숭이와 생쥐의 비교 miRNA 전사체는 MYOC가 뇌로의 크립토코커스 네오포르만스 침입에 대한 억제제임을 보여줍니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] 유전자 메커니즘, [키워드] AIDS Brain brain dissemination brains C. neoforman C. neoformans caused Central nervous system centric clinical samples clinically CNS Comparative Cryptococcal meningoencephalitis cryptococcosis Cryptococcus neoforman Cryptococcus neoformans cytoskeleton dissemination enhancer facilitate fungal Fungal infection help HIV/AIDS HIV/AIDS patient HIV/AIDS patients host-pathogen interactions hosts human pathogen Immune cell immune cells individuals Infection inhibitor inhibitors Invasion macaque Macrophage mechanism meningoencephalitis mice miRNA miRNA transcriptome. MYOC myocilin Pathogenic microorganisms pathway Patient patients with COVID-19 performed Prevalence regulated response reveal Transcriptome transcriptomics Trojan horse [DOI] 10.1080/22221751.2022.2081619 PMC 바로가기 [Article Type] Article
Clinical microbiology in detection and identification of emerging microbial pathogens: past, present and futureArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] 진단, [키워드] Antibody assays Antigen Bacterial pathogens change clinical clinical microbiology Clinical practice COVID-19 COVID-19 pandemic Critical Culture Diagnosis diagnostics Diseases evidenced Genomics Gram stain IMPROVE in vitro Infectious disease metabolomics microbial microbial infections Molecular biology MONITOR morphology nucleic acid nucleic acid amplification outcome pathogen detection Patient point of care progression proteomics Revolutionary transcriptomics transcriptomics. [DOI] 10.1080/22221751.2022.2125345 PMC 바로가기
Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
Early suppression of antiviral host response and protocadherins by SARS-CoV-2 Spike protein in THP-1-derived macrophage-like cellsArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Alpha Antiviral approved Cell cells cellular cellular response change coronavirus Coronavirus disease-19 COVID-19 cytokine differentially expressed downregulation Effect effort expressing expression highlight homeostasis host cells host response humoral immune responses induce Infection information interferon intrinsic involved medium pandemic pathogenic PROTECT Protein reflected Result S protein SARS-CoV-2 spike Spike protein the S protein transcriptomic transcriptomics transcriptomics. type I Vaccination strategies Vaccine variety while [DOI] 10.3389/fimmu.2022.999233 PMC 바로가기
Longitudinal characterization of circulating neutrophils uncovers phenotypes associated with severity in hospitalized COVID-19 patientsArticle Published on 2022-10-182022-11-15 Journal: Cell Reports Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome antibody profiling blood sample cell death circulating neutrophil contributing to Control coronavirus COVID-19 degranulation disease disease severity driver dysregulated elevated experiment functions G-MDSC gene expression signature Granulocytic healthy donor hospitalized COVID-19 hospitalized COVID-19 patient Humoral response identify IgA IgA antibody IgG antibody Immunoglobulin induce longitudinal Mortality NETosis neutrophil Neutrophils Patient phagocytosis phenotype plasma plasma proteomics response RNA sequencing SARS-CoV-2 severe coronavirus disease severe COVID-19 severe disease Severe patient severity Subtypes survived transcriptomics transcriptomics. [DOI] 10.1016/j.xcrm.2022.100779 PMC 바로가기
Development of Single-Cell Transcriptomics and Its Application in COVID-19Article Published on 2022-10-162022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory syndrome application ARDS asymptomatic infection basic reproduction number caused claimed clinical manifestation clinical manifestations component coronavirus coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 research Critical death development differentially expressed gene examined Health immune immune response IMPROVE individual cells mutate offered over physiological resulting SARS-CoV-2 Sequencing single-cell Single-cell transcriptomics. syndrome transcriptomics Treatment variety [DOI] 10.3390/v14102271 PMC 바로가기
Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics studyArticle Published on 2022-10-142022-11-15 Journal: eLife [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Abuse Accelerator Antibody Response association Biomarker BNT162b2 characterized clinical trial coronavirus Course COVID-19 COVID-19 patients Critical CXCL10 cytokine dataset develop Disease progression Donor drug early IFN signaling Eiger BioPharmaceuticals enrolled Enrollment heterogeneity Host identify immune immune marker immune response immune signature immunological immunology independent individual Infection Infectious disease Inflammation machine-learning majority marker MCP-3 MCP1 Medicine memory Mild mRNA vaccination natural infection outcome Outpatient outpatients Patient Pfizer-BioNTech plasma plasma protein Post-infection predict Predictive Predictive modeling proteomics provided receiving RIG-I SARS-CoV-2 SARS-CoV-2-infected patients severe symptoms Stanford Stanford University subsequent systems immunology T cell T cell memory the antibody response trajectory transcriptomics Vaccine viral shedding Virological viruses viruses. with COVID-19 [DOI] 10.7554/eLife.77943 PMC 바로가기
Redox imbalance in COVID-19 pathophysiologyArticle Published on 2022-10-012022-11-16 Journal: Redox Biology [Category] 치료기술, [키워드] alteration analysis antioxidant Ascorbate association biochemical assay Blood circulating Clinical outcome contributing to control subject COVID COVID-19 COVID-19 infection Diagnosis electron Electron paramagnetic resonance enrichment analysis enrolled EPR evaluate greater ICAM-1 ICU indicated Inflammation Inflammatory intensive care marker Mortality mRNA Multiplex assay multivariate non-ICU non-specific Oxidant oxidative stress parameter pathophysiologic pathophysiology pathway performed Peripheral blood positive predict predicted quantified redox Redox imbalance reducing reduction in repetition required SARS-CoV-2 Sequencing serum Serum level significant increase subject subjects therapeutic strategy Topic transcriptomics TSLP uric acid Uric acid. Vascular VCAM-1 Virus Disease was performed [DOI] 10.1016/j.redox.2022.102465 PMC 바로가기